CATALYST-FREE THREE-COMPONENT SYNTHESIS OF 2-AMINO-4,6-DIARYLPYRIDINE-3-CARBONITRILES UNDER SOLVENT-FREE CONDITIONS

Authors

  • Mohammad Hosein Sayahi Department of Chemistry, Payame Noor University, P. O. Box 19395-3697, Tehran, Iran
  • Seyyed Jafar Saghanezhad ACECR-Production Technology Research Institute, P. O. Box 61396-84689, Ahvaz, Iran
  • Mohammad Mahdavi Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, P. O. Box 14117-13137, Tehran, Iran

DOI:

https://doi.org/10.1007/4613

Keywords:

acetophenone oximes, 2-amino-4, 6-diarylpyridine-3-carbonitriles, solvent-free synthesis.

Abstract

A novel efficient one-pot synthesis of 2-amino-4,6-diarylpyridine-3-carbonitriles is described. Method involves heating the mixture of an acetophenone oxime, aldehyde, and malononitrile without any catalyst under solvent-free conditions to give the title compounds in good to high yields.

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Published

2019-08-15

Issue

Vol. 55 No. 8 (2019)

Section

Original Papers