Open Access
Subscription Access
THE REACTION OF ETHYL 2-OXO-3-(4-OXO-4Н-CHROMEN-2-YL)PROPANOATES WITH S-METHYLISOTHIOSEMICARBAZIDE HYDROIODIDE
Abstract
Ethyl 2-oxo-3-(4-oxo-4Н-chromen-2-yl)propanoates reacted with S-methylisothiosemicarbazide hydroiodide at the ethoxalyl group,
forming 3-methylsulfanyl-6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazin-5(2H)-ones upon refluxing in pyridine (40–50% yields) or 6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazine-3,5(2Н,4Н)-diones when refluxed in ethanol (37–74% yields).
forming 3-methylsulfanyl-6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazin-5(2H)-ones upon refluxing in pyridine (40–50% yields) or 6-[(4-oxo-4Н-chromen-2-yl)methyl]-1,2,4-triazine-3,5(2Н,4Н)-diones when refluxed in ethanol (37–74% yields).
Keywords
6-azauracil, ethyl 2-oxo-3-(4-oxo-4Н-chromen-2-yl)propanoates, hydrazine hydrate, S-methylisothiosemicarbazide, pyrazole.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv