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SYNTHESIS AND AMINOMETHYLATION OF REGIOISOMERIC 6-HYDROXY-4-METHYL- AND 4-HYDROXY-6-METHYLAURONES

Светлана П. Бондаренко, Антонина В. Попова, Михаил С. Фрасинюк
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Abstract


The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl- 6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The use of an excess of the aminals allows to obtain 5,7-bis(aminomethyl) derivatives of 6-hydroxy-4-methylaurones.

Keywords


benzofuran-3(2Н)-one, 4-hydroxy-6-methylaurone, 6-hydroxy-4-methylaurone, aminomethylation, Mannich bases.

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