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RECENT PROGRESS IN THE SYNTHESIS OF MORPHOLINES

Vitalii A. Palchykov, Valentyn A. Chebanov
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Abstract


The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2amino alcohols, aziridines, epoxides, and related compounds. Special attention is paid to the syntheses performed in a stereoselective manner and using transition metal catalysis. Selected works published since 2013 are covered.

 


Keywords


1,2-amino alcohols, aziridines, epoxides, morpholines, 1,4-oxazinanes.

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