RECENT PROGRESS IN THE SYNTHESIS OF MORPHOLINES

Authors

  • Vitalii A. Palchykov Oles Honchar Dnipro National University
  • Valentyn A. Chebanov SSI “Institute for Single Crystals” NAS of Ukraine,

DOI:

https://doi.org/10.1007/4834

Keywords:

1, 2-amino alcohols, aziridines, epoxides, morpholines, 4-oxazinanes.

Abstract

The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2amino alcohols, aziridines, epoxides, and related compounds. Special attention is paid to the syntheses performed in a stereoselective manner and using transition metal catalysis. Selected works published since 2013 are covered.

 

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Published

2019-05-22

Issue

Vol. 55 No. 4/5 (2019): In memory of Professor Valerii Dmitrievich Orlov

Section

Review Articles