Open Access Open Access  Restricted Access Subscription Access

SATURATED SPIROCYCLIC NITROGEN-CONTAINING HETEROCYCLES WITH gem-DIFLUOROCYCLOALKANE MOIETIES

Oleksandr O. Grygorenko, Kostiantyn P. Melnykov
Cover Image

Abstract


Recent advances in synthetic and medicinal chemistry of saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties are surveyed, including results published in the last decade. In particular, gem-difluoro-substituted derivatives of azaspiro[2.n]alkanes, azaspiro[3.n]alkanes, azaspiro[4.5]decane, and other spirocyclic scaffolds are discussed.

Keywords


organofluorine compounds; heteroaliphatic compounds; spiro compounds

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv