SATURATED SPIROCYCLIC NITROGEN-CONTAINING HETEROCYCLES WITH <i>gem</i>-DIFLUOROCYCLOALKANE MOIETIES

Авторы

  • Oleksandr O. Grygorenko Enamine Ltd; Taras Shevchenko National University of Kyiv
  • Kostiantyn P. Melnykov Enamine Ltd; Taras Shevchenko National University of Kyiv

DOI:

https://doi.org/10.1007/5091

Ключевые слова:

organofluorine compounds, heteroaliphatic compounds, spiro compounds

Аннотация

Recent advances in synthetic and medicinal chemistry of saturated spirocyclic nitrogen-containing heterocycles with gem-difluorocycloalkane moieties are surveyed, including results published in the last decade. In particular, gem-difluoro-substituted derivatives of azaspiro[2.n]alkanes, azaspiro[3.n]alkanes, azaspiro[4.5]decane, and other spirocyclic scaffolds are discussed.

Загрузки

Опубликован

2019-08-14

Выпуск

Том 55 № 8 (2019)

Раздел

Гетероциклы в фокусе