SYNTHESIS OF 5-SUBSTITUTED 2-YLIDENE-1,3-THIAZOLIDIN-4-ONE DERIVATIVES AND EVALUATION OF THEIR ANTICANCER AND ANTIOXIDANT ACTIVITIES

Abstract

Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N,S-acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.