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SYNTHESIS OF 5-SUBSTITUTED 2-YLIDENE-1,3-THIAZOLIDIN-4-ONE DERIVATIVES AND EVALUATION OF THEIR ANTICANCER AND ANTIOXIDANT ACTIVITIES

Khaled F. Saied, Kamal A. Kandeel, Salwa S. Abdelwahab, Osama M. Ahmed
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Abstract


Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N,S-acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.


Keywords


ketene N,S-acetal; malononitrile; phenyl isothiocyanate; 1,3-thiazolidin-4-one; anticancer activity; antioxidant activity; cyclocondensation; transesterification.

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