SYNTHESIS OF 5-SUBSTITUTED 2-YLIDENE-1,3-THIAZOLIDIN-4-ONE DERIVATIVES AND EVALUATION OF THEIR ANTICANCER AND ANTIOXIDANT ACTIVITIES

Authors

  • Khaled F. Saied Nahda University
  • Kamal A. Kandeel Ain Shams University
  • Salwa S. Abdelwahab Future University in Egypt
  • Osama M. Ahmed Beni-Suef University

DOI:

https://doi.org/10.1007/5126

Keywords:

ketene N, S-acetal, malononitrile, phenyl isothiocyanate, 1, 3-thiazolidin-4-one, anticancer activity, antioxidant activity, cyclocondensation, transesterification.

Abstract

Novel 5-(aroyl)methyl- and 5-(aroyl)methylen-2-ylidene-1,3-thiazolidin-4-ones have been prepared in high yields using ketene N,S-acetal salts, obtained from phenyl isothiocyanate and propanedinitrile or ethyl cyanoacetate. Several of the newly synthesized 1,3-thiazolidin-4-one derivatives demonstrate high antioxidant and anticancer activities.

Author Biographies

Khaled F. Saied, Nahda University

Department of chemistry

Lecturer

Kamal A. Kandeel, Ain Shams University

Chemistry Department

Salwa S. Abdelwahab, Future University in Egypt

Faculty of Pharmaceutical Sciences and Pharmaceutical Industries,

Osama M. Ahmed, Beni-Suef University

Zoology Department

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Published

2019-09-27

Issue

Vol. 55 No. 10 (2019)

Section

Original Papers