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NEW 3,4-BIS(INDOL-1-YL)MALEIMIDES AS PROTEIN KINASE INHIBITORS

Алексей А. Панов, Сергей А. Лакатош, Михаэль Х. Г. Куббутат, Любовь Г. Деженкова, Франк Тотцке, Кристоф Шехтеле
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Abstract


Several previously unknown derivatives of 3,4-bis(indol-1-yl)maleimide, as well as 3-(2,3-dihydroindol-1-yl)-4-(indol-1-yl)maleimide were synthesized as potential analogs for a known series of protein kinase inhibitors BIS I, IV, IX containing the structural motif of 3,4-bis(indol-3-yl)maleimide. The activity of these synthesized compounds was characterized with regard to several human protein kinases and their cytotoxicity was determined.

Keywords


indole; indolylmaleimides; antitumor drugs; protein kinases; protein kinase inhibitors.

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