TETRAHYDROISOQUINOLINE-BASED NON-PEPTIDOMIMETIC PLASMEPSIN INHIBITORS

Authors

  • Linda Kinena Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Vita Ozola Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/5499

Keywords:

plasmepsins, tetrahydroisoquinoline, malaria, Pictet–Spengler reaction, X-ray analysis.

Abstract

A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.

Author Biographies

Linda Kinena, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

Laboratory of Advanced Technologies for Organic Synthesis, Research assistant

Vita Ozola, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

Laboratory of Advanced Technologies for Organic Synthesis, Principal Scientist

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Published

2020-01-31

Issue

Vol. 56 No. 1 (2020)

Section

Original Papers