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TETRAHYDROISOQUINOLINE-BASED NON-PEPTIDOMIMETIC PLASMEPSIN INHIBITORS

Linda Kinena, Vita Ozola
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Abstract


A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.


Keywords


plasmepsins; tetrahydroisoquinoline; malaria; Pictet–Spengler reaction; X-ray analysis.

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