

TETRAHYDROISOQUINOLINE-BASED NON-PEPTIDOMIMETIC PLASMEPSIN INHIBITORS

Abstract
A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.
Keywords
plasmepsins; tetrahydroisoquinoline; malaria; Pictet–Spengler reaction; X-ray analysis.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv