TETRAHYDROISOQUINOLINE-BASED NON-PEPTIDOMIMETIC PLASMEPSIN INHIBITORS

Авторы

  • Linda Kinena Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia
  • Vita Ozola Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

DOI:

https://doi.org/10.1007/5499

Ключевые слова:

plasmepsins, tetrahydroisoquinoline, malaria, Pictet–Spengler reaction, X-ray analysis.

Аннотация

A series of tetrahydroisoquinoline derivatives containing different aryl substituents were designed and synthesized using Pictet–Spengler reaction as the key step. The synthesized tetrahydroisoquinoline derivatives displayed micromolar inhibitory activity against plasmepsins I and II.

Биографии авторов

Linda Kinena, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

Laboratory of Advanced Technologies for Organic Synthesis, Research assistant

Vita Ozola, Latvian Institute of Organic Synthesis, 21 Aizkraukles St., Riga LV-1006, Latvia

Laboratory of Advanced Technologies for Organic Synthesis, Principal Scientist

Загрузки

Опубликован

2020-01-31

Выпуск

Том 56 № 1 (2020)

Раздел

Оригинальные статьи