1-(CYANOACETYL)-3,5-DIMETHYLPYRAZOLE AS AN EFFECTIVE ALTERNATIVE TO CYANOACETIC ESTER IN THE SYNTHESIS OF 2,6-DIOXOPIPERIDINE-3,5-DICARBONITRILE DERIVATIVES

Е. А. Чигорина
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Abstract


1-(Cyanoacetyl)-3,5-dimethylpyrazole reacted with 2-cyanoacrylamides in the presence of triethylamine with the formation of triethylammonium salts of 4-monosubstituted-2,6-dioxopiperidine-3,5-dicarbonitriles (Guareschi imides) or the products of their oxidation, the 4-aryl-3,5-dicyano-6‑oxo-1,6-dihydropyridin-2-olates.

Author: E. A. Chigorina

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (4), pp 574-585

http://link.springer.com/article/10.1007/s10593-013-1284-3

Keywords


1-(cyanoacetyl)-3,5-dimethylpyrazole; 2-cyanoacrylamides; 2,6-dioxopiperidine-3,5-dicarbonitriles; ethyl cyanoacetate; glutarimides; Guareschi imides; Michael addition; oxidation

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