ELECTROPHILIC REACTIONS AS METHODS OF MODIFICATION OF PYRROLOBENZIMIDAZOLONES AND PYRROLOQUINAZOLINONES

Authors

  • Вячеслав С. Гринёв Saratov State University named after N. G. Chernyshevsky, 83 Astrakhanskaya St,, Saratov 410012 Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13 Entuziastov Ave., Saratov 410049
  • Алевтина Ю. Егорова Saratov State University named after N. G. Chernyshevsky, 83 Astrakhanskaya St,, Saratov 410012

DOI:

https://doi.org/10.1007/5756

Keywords:

pyrrolo[1, 2-a]benzimidazolones, pyrrolo[2, 1-b]quinazolinones, acylation, bioavailability, electrophilic reactions, lipophilicity, methylation, trifluoroacylation

Abstract

The publication presents a number of modifications based on electrophilic reactions of previously synthesized biologically active benzannulated pyrrolo[1,2-a]imidazolones and pyrrolo[2,1-b]quinazolinones, which make it possible to widely change the physicochemical properties of molecules. Quantitative assessments of the lipophilicity of all synthesized compounds were carried out, on the basis of which conclusions were made regarding the advisability of introducing alkyl and trifluoroacetyl groups to increase the bioavailability of compounds by increasing their lipophilicity to 40%.

Authors: Vyacheslav S. Grinev*, Alevtina Yu. Egorova

Author Biographies

Вячеслав С. Гринёв, Saratov State University named after N. G. Chernyshevsky, 83 Astrakhanskaya St,, Saratov 410012 Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, 13 Entuziastov Ave., Saratov 410049

Кафедра органической и биоорганической химии, доцент;

Лаборатория биохимии, с.н.с.

Алевтина Ю. Егорова, Saratov State University named after N. G. Chernyshevsky, 83 Astrakhanskaya St,, Saratov 410012

Кафедра органической и биоорганической химии, профессор;

Downloads

Published

2020-08-19

Issue

Vol. 56 No. 7 (2020): Synthesis and transformations of heterocycles under electrophilic conditions

Section

Original Papers