SYNTHESIS OF ANTIAROMATIC THIAZINOINDOLIZINES BASED ON ELECTROPHILIC CYCLIZATIONS OF INDOLIZINE-5-THIONE

Abstract

Alkylation of indolizinethione at the sulfur atom by the action of RCOCH₂Br (R = Me, Ar, CO₂Me, OEt) leads to thioethers, and subsequent closure of the thiazine ring of which leads to the formation of stable antiaromatic thiazino[4,3,2-cd]indolizines.

Authors: Eugene V. Babaev*, Aleksandra А. Nevskaya, Ilya V. Dlynnikh, Victor B. Rybakov