

SYNTHESIS OF ISOXAZOLYLPYRROLONES BY THREE-COMPONENT REACTION OF α-KETOGLUTARIC ACID OR ITS DIETHYL ESTER WITH 3-AMINO-5-METHYLISOXAZOLE AND AROMATIC ALDEHYDES

Abstract
[2-Aryl-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acids and their esters were synthesized by the three-component reaction of α-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes.
Keywords
3-amino-5-methylisoxazole; α-ketoglutaric acid; [1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acid; multicomponent reaction.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv