Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF ISOXAZOLYLPYRROLONES BY THREE-COMPONENT REACTION OF α-KETOGLUTARIC ACID OR ITS DIETHYL ESTER WITH 3-AMINO-5-METHYLISOXAZOLE AND AROMATIC ALDEHYDES

Yana I. Sakhno, Oleksandr V. Radchenko, Elena A. Muravyova, Svitlana M. Sirko, Svitlana V. Shishkina, Vladimir I. Musatov, Sergey M. Desenko, Valentyn A. Chebanov
Cover Image

Abstract


[2-Aryl-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acids and their esters were synthesized by the three-component reaction of α-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes.


Keywords


3-amino-5-methylisoxazole; α-ketoglutaric acid; [1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]acetic acid; multicomponent reaction.

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv