

SYNTHESIS OF 2-TRIAZOLYLPURINE PHOSPHONATES

Abstract
A series of novel compounds containing triazole and phosphonate moieties were obtained under mild conditions. Reactions of 2,6-bis(triazolyl)purine acyclic nucleoside phosphonates, in which triazole ring at C-6 atom of purine was acting as a good leaving group, and N- or S-nucleophiles allowed to obtain the respective 2-triazolylpurine phosphonates in 62–87% yields.
Keywords
2,6-bis(triazolyl)purines; purine phosphonates; 2-triazolylpurines; nucleophilic aromatic substitution.
Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv