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SYNTHESIS OF 2-TRIAZOLYLPURINE PHOSPHONATES

Zigfrīds Kapilinskis, Irina Novosjolova, Ērika Bizdēna, Māris Turks
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Abstract


A series of novel compounds containing triazole and phosphonate moieties were obtained under mild conditions. Reactions of 2,6-bis(triazolyl)purine acyclic nucleoside phosphonates, in which triazole ring at C-6 atom of purine was acting as a good leaving group, and N- or S-nucleophiles allowed to obtain the respective 2-triazolylpurine phosphonates in 62–87% yields.

Keywords


2,6-bis(triazolyl)purines; purine phosphonates; 2-triazolylpurines; nucleophilic aromatic substitution.

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