SYNTHESIS OF 2-TRIAZOLYLPURINE PHOSPHONATES

Authors

  • Zigfrīds Kapilinskis Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3 Paula Valdena St., Riga LV-1048, Latvia
  • Irina Novosjolova Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3 Paula Valdena St., Riga LV-1048, Latvia
  • Ērika Bizdēna Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3 Paula Valdena St., Riga LV-1048, Latvia
  • Māris Turks Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, 3 Paula Valdena St., Riga LV-1048, Latvia

DOI:

https://doi.org/10.1007/6037

Keywords:

2, 6-bis(triazolyl)purines, purine phosphonates, 2-triazolylpurines, nucleophilic aromatic substitution.

Abstract

A series of novel compounds containing triazole and phosphonate moieties were obtained under mild conditions. Reactions of 2,6-bis(triazolyl)purine acyclic nucleoside phosphonates, in which triazole ring at C-6 atom of purine was acting as a good leaving group, and N- or S-nucleophiles allowed to obtain the respective 2-triazolylpurine phosphonates in 62–87% yields.

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Published

2021-01-26

Issue

Vol. 57 No. 1 (2021)

Section

Original Papers