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A CONVENIENT APPROACH TO THE SYNTHESIS OF 1-HALOMETHYL-SUBSTITUTED 2,4,5,6-TETRAHYDRO-1H-IMIDAZO[1,2-a][1]BENZAZEPINES

Иванна Ю. Данилюк, Валентина С. Толмачева, Эдуард Б. Русанов, Михаил В. Вовк
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Abstract


Intramolecular halocyclization of N-allyl-4,5-dihydro-3H-1-benzazepin-2-amines, obtained by consecutive methylation and allylamination of benzazepin-2-ones, by the action of N-iodo(bromo)succinimide in acetonitrile at room temperature lead to the formation 1-(iodo(bromo)methyl)-2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines in high yields.

 


Keywords


N-allyl-4,5-dihydro-3H-1-benzazepin-2-amines; benzazepines; 1-(halomethyl)-2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines; 2-methoxy-4,5-dihydro-3H-1-benzazepinones; electrophilic cyclization.

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