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THE SYNTHESIS OF NOVEL 1-HETARYLMETHYLIDENE-4-SULFANYLFURO[3,4-c]PYRIDIN-3(1H)-ONES

Елена А. Кайгородова, Наталья А. Макарова, Леонид Д. Конюшкин, Геннадий Д. Крапивин
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Abstract


1-Hetarylmethylidene-4-sulfanylfuro[3,4-c]pyridin-3-ones were accessed from 4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one employing a condensation reaction with heteroaromatic aldehydes followed by thioalkylation, but not vice versa. Alkylation of 1-hetarylmethylidene-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-ones in an alkaline medium proceeded regioselectively at the sulfur atom to form sulfanyl derivatives.

Authors: Elena А. Kaigorodova, Natal'ya А. Makarova, Leonid D. Konyushkin, Gennady D. Krapivin*


Keywords


1-hetarylmethylidene-6-methyl-4-sulfanyl-1,3-dihydrofuro[3,4-c]pyridin-3-ones; 1-hetarylmethylidene-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-one; alkylation

Full Text: PDF (Russian) Supplementary File(s): Supporting information (3MB)


 

 

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