THE SYNTHESIS OF NOVEL 1-HETARYLMETHYLIDENE-4-SULFANYLFURO[3,4-<i>c</i>]PYRIDIN-3(1<i>H</i>)-ONES

Authors

  • Елена А. Кайгородова Kuban State Agrarian University named after I. T. Tribulin, 13 Kalinina St., Krasnodar 350004, Russia
  • Наталья А. Макарова Kuban State Agrarian University named after I. T. Tribulin, 13 Kalinina St., Krasnodar 350004, Russia
  • Леонид Д. Конюшкин N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Ave., Moscow 119991
  • Геннадий Д. Крапивин Kuban State Technological University, 2 Moskovskaya St., Krasnodar 350072

DOI:

https://doi.org/10.1007/6736

Keywords:

1-hetarylmethylidene-6-methyl-4-sulfanyl-1, 3-dihydrofuro[3, 4-c]pyridin-3-ones, 1-hetarylmethylidene-6-methyl-4-thioxo-4, 5-dihydrofuro[3, 4-c]pyridin-3-one, alkylation

Abstract

1-Hetarylmethylidene-4-sulfanylfuro[3,4-c]pyridin-3-ones were accessed from 4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one employing a condensation reaction with heteroaromatic aldehydes followed by thioalkylation, but not vice versa. Alkylation of 1-hetarylmethylidene-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3-ones in an alkaline medium proceeded regioselectively at the sulfur atom to form sulfanyl derivatives.

Authors: Elena А. Kaigorodova, Natal'ya А. Makarova, Leonid D. Konyushkin, Gennady D. Krapivin*

Author Biography

Елена А. Кайгородова, Kuban State Agrarian University named after I. T. Tribulin, 13 Kalinina St., Krasnodar 350004, Russia

кафедра биоорганической химии, главный научеый сотрудник

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Published

2022-09-21

Issue

Vol. 58 No. 8/9 (2022)

Section

Original Papers