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ONE-POT TRANSFORMATIONS OF TETRACYANOCYCLOPROPANES INTO HIGHLY FUNCTIONALIZED PYRIDINES

Анастасия И. Ершова, Олег Е. Насакин, Олег В. Ершов
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Abstract


An effective method has been developed for the synthesis of 2-amino-4-aryl-6-chloropyridine-3,5-dicarbonitriles from 3-arylcyclopropane-1,1,2,2-tetracarbonitriles by treating the starting materials with sodium hydride in anhydrous DMF, followed by HCl in isopropanol.

 


Keywords


cyclopropane; nitriles; polycyano compounds; pyridine; one-pot synthesis; recyclization.

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv