Synthesis of 1,4-dihydropyridines having an N-alkylpyridinium substituent at the 4-position and their affinity towards liposomal membranes

Authors

  • H. В. Макарова Latvian Institute of Organic Synthesis, Riga LV-1006
  • Ж. В. Коронова Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. В. Плотниеце Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Я. Тирзите Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Д. Тиpзит Latvian Institute of Organic Synthesis, Riga LV-1006
  • Г. Я. Дyбypc Latvian Institute of Organic Synthesis, Riga LV-1006

Abstract

There has been synthesized a series of 1,4-dihydropyridines having an N-alkylpyridinium substituent at position 4 with a varying length of hydrocarbon chain. Their affinity to model (liposomal) membranes has been studied. It was found that this affinity increased with lengthening of the hydrocarbon chain on the N-pyridinium substituent at the 4-position of the 1,4-dihydropyridine ring. However, lengthening of the hydrocarbon chain in the 3,5-ester groups of the 1,4-dihydropyridine ring led to a decrease in the binding to the liposome when a 4-(N-hexadecylpyridinium) substituent was present.

How to Cite
Makarova, N. V.; Koronova, Z. V.; Plotnietse, A. V.; Tirzite, D. Ya.; Tirzit, G. D.; Duburs, G. Ya. Chem. Heterocycl. Compd. 1995, 31, 969. [Khim. Geterotsikl. Soedin. 1995, 1112.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01170324

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Published

1995-08-25

Issue

No. 8 (1995)

Section

Original Papers