Synthesis and some properties of 6-β-oxoalkyl(aralkyl, hetaralkyl, cycloalkyl)thiopurines

Authors

  • П. М. Кочергин Zaporozh'e State Medicinal Institute, Zaporozh'e 330074
  • М. Ю. Громов Zaporozh'e State Medicinal Institute, Zaporozh'e 330074
  • E. В. Александрова Zaporozh'e State Medicinal Institute, Zaporozh'e 330074
  • C. Я. Скачиловa Center for the Chemistry of Medicinals, All-Russian Chemico-Pharmaceutical Scientific Research Institute, Moscow 119815

Abstract

The reaction of 6-purinethione with α-haloketones has given a series of new 6-β-oxoalkyl(aralkyl, hetaralkyl, cycloalkyl)thiopurines. Their alkylation in position 9 and acid hydrolysis to hypoxanthine and its 9-alkyl derivatives has been studied. The hydrolysis of the acetals of 6-formylmethylthiopurine and the oxidation of 6-(2,3-dihydroxypropyl)thiopurine leads to 6-formylmethylthiopurine, which shows a ring-chain tautomerism and exists in the form of 7-hydroxy-7,8-dihydrothiazolo[2,3-i]purine.

How to Cite
Kochergin, P. M.; Gromov, M. Yu.; Aleksandrova, E. V.; Skachilova, S. Ya. Chem. Heterocycl. Compd. 1993, 29, 1332. [Khim. Geterotsikl. Soedin. 1993, 1548.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF00532036

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Published

1993-11-25

Issue

No. 11 (1993)

Section

Original Papers