2-PHENYLPYRROLE: ONE-POT SELECTIVE SYNTHESIS FROM ACETOPHENONE OXIME AND ACETYLENE BY A TROFIMOV REACTION

Abstract

We have developed a technologically orientated, one-pot way of synthesis of high purity 2-phenylpyrrole in 74% yield by treatment of acetophenone oxime with acetylene in the KOH–DMSO system. The reaction is carried out at 135-150ºC under an acetylene atmospheric pressure. The synthesis was performed in laboratory (glass apparatus) and in a large scale (10 l reaction vessel).

Authors: A. I. Mikhaleva, O. V. Petrova, and L. N. Sobenina.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (11), pp 1367-1371

http://link.springer.com/article/10.1007/s10593-012-0922-5