STUDIES OF BENZOXAZINES. 16. SYNTHESIS AND REACTIVITY OF 2,4-SUBSTITUTED 4<i>H</i>-3,1-BENZOXAZINES

Authors

  • Е. В. Громачевская Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University
  • В. Г. Кульневич Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University
  • Т. П. Косулина Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University

DOI:

https://doi.org/10.1007/1351

Keywords:

2-aminopyridines, 4H-3, 1-benzoxazines, mass spectroscopic fragmentation, nucleophilic substitution, electrophilic substitution, synthesis

Abstract

A novel method has been developed for preparation of substituted 4H-3,1-benzoxazines via formation of tetrafluoroborates. The substitution of halogen in 2-(α-haloalkyl)-4,4-diphenyl-4H-3,1-benzoxazines by NH and SH nucleophiles was performed. The effect of electrophilic substitution in the annelated aromatic ring in a series of 2,4-substituted 4H-3,1-benzoxazines has been studied.

Authors: E. V. Gromachevskaya, V. G. Kul'nevich, and T. P. Kosulina.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (11), pp 1405-1414

http://link.springer.com/article/10.1007/s10593-012-0928-z

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Published

2013-12-12

Issue

No. 11 (2011)

Section

Original Papers