SYNTHESIS OF 1-METHOXY-4-(2-MORPHOLINOETHYL)-3,3-DIPHENYLPYRROLIDIN-2-ONE

Abstract

Doxapram has long been used as intravenously–administered drug for treatment of acute respiratory insufficiency. As a part of our research program toward development of novel respiratory stimulants we were interested in synthesis of Doxapram analogues. Herein we report a concise synthesis of N-methoxypyrrolidinone.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 496-499

http://link.springer.com/article/10.1007/s10593-013-1274-5