MICHAEL ADDITION TO UNPROTECTED 3-(2-NITROVINYL)INDOLES UNDER THE CONDITIONS OF MICROWAVE SYNTHESIS
Keywords:indole, nitroalkenes, addition, Michael reaction
A novel highly efficient preparative method for the synthesis of substituted indoles using conjugate addition of nucleophiles to 3-(2-nitrovinyl)indoles has been developed. The addition of nucleophiles generated in the presence of a base from CH acids was investigated. The studied reactions proceed quickly and smoothly under the conditions of microwave activation and do not require protection of the indole nitrogen atom.
Authors: Alexander V. Aksenov*, Nikolai A. Aksenov, Anton A. Skomorokhov, Inna V. Aksenova, Georgii D. Gryaznov, Leonid G. Voskressensky, Michael A. Rubin*