MICHAEL ADDITION TO UNPROTECTED 3-(2-NITROVINYL)INDOLES UNDER THE CONDITIONS OF MICROWAVE SYNTHESIS

Authors

  • Александр В. Аксенов North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009
  • Николай А. Аксенов North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009
  • Антон А. Скоморохов North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009
  • Инна В. Аксенова North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009
  • Георгий Д. Грязнов North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009
  • Леонид Г. Воскресенский Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198
  • Михаил А. Рубин The University of Kansas, 1251 Wescoe Hall Dr., Lawrence, KS 66045-7582

DOI:

https://doi.org/10.1007/3376

Keywords:

indole, nitroalkenes, addition, Michael reaction

Abstract

A novel highly efficient preparative method for the synthesis of substituted indoles using conjugate addition of nucleophiles to 3-(2-nitrovinyl)indoles has been developed. The addition of nucleophiles generated in the presence of a base from CH acids was investigated. The studied reactions proceed quickly and smoothly under the conditions of microwave activation and do not require protection of the indole nitrogen atom.

Authors: Alexander V. Aksenov*, Nikolai A. Aksenov, Anton A. Skomorokhov, Inna V. Aksenova, Georgii D. Gryaznov, Leonid G. Voskressensky, Michael A. Rubin*

 

Author Biography

Георгий Д. Грязнов, North-Caucasus Federal University, 1а Pushkin St., Stavropol 355009

Associate Professor,

Department of Chemistry

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Published

2016-12-07

Issue

Vol. 52 No. 11 (2016): Non-classical methods of activation in chemistry of heterocyclic compounds

Section

Original Papers