STUDY ON THE SCALE-UP OF PHASE-TRANSFER-CATALYZED AZO COUPLING REACTIONS IN FLOW REACTORS

Authors

  • Faith Akwi Nelson Mandela Metropolitan University, P. O. Box 77 000, University Way, Port Elizabeth, 6031
  • Paul Watts Nelson Mandela Metropolitan University, P. O. Box 77 000, University Way, Port Elizabeth, 6031

DOI:

https://doi.org/10.1007/3401

Keywords:

heterocycles, azo coupling, flow chemistry, microreactors

Abstract

We report the first systematic study on the channel size effect in various microreactor systems on the efficiency of phase-transfer-catalyzed azo coupling reactions. The optimum scaled-up channel diameter was 0.5 mm, which facilitated the synthesis of diazo compounds in high yields.

 

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Published

2016-12-01

Issue

Vol. 52 No. 11 (2016): Non-classical methods of activation in chemistry of heterocyclic compounds

Section

Original Papers