SYNTHESIS AND BIOLOGICAL ACTIVITY OF HETEROCYCLIC BORNEOL DERIVATIVES

Authors

  • Anastasiya S. Sokolova Novosibirsk Institute of Organic Chemistry
  • Olga I. Yarovaya Novosibirsk State University
  • Anna A. Shtro Department of Chemotherapy, Research Institute of Influenza
  • Marina S. Borisova Novosibirsk Institute of Organic Chemistry
  • Ekaterina A. Morozova Novosibirsk Institute of Organic Chemistry
  • Tatyana G. Tolstikova Novosibirsk Institute of Organic Chemistry
  • Vladimir V. Zarubaev Department of Chemotherapy, Influenza Research Institute
  • Nariman F. Salakhutdinov Novosibirsk Institute of Organic Chemistry

DOI:

https://doi.org/10.1007/3651

Keywords:

1H-benzimidazole-2-thiol, benzoxazole-2-thiol, benzthiazole-2-thiol, (–)-borneol, analgesic activity, antiulcer activity, antiviral activity

Abstract

A series of novel heterocyclic derivatives of (–)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

 

Author Biographies

Anastasiya S. Sokolova, Novosibirsk Institute of Organic Chemistry

Olga I. Yarovaya, Novosibirsk State University

Anna A. Shtro, Department of Chemotherapy, Research Institute of Influenza

Marina S. Borisova, Novosibirsk Institute of Organic Chemistry

Ekaterina A. Morozova, Novosibirsk Institute of Organic Chemistry

Tatyana G. Tolstikova, Novosibirsk Institute of Organic Chemistry

Vladimir V. Zarubaev, Department of Chemotherapy, Influenza Research Institute

Nariman F. Salakhutdinov, Novosibirsk Institute of Organic Chemistry

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Published

2017-04-07

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Original Papers