SYNTHESIS AND BIOLOGICAL ACTIVITY OF HETEROCYCLIC BORNEOL DERIVATIVES

Авторы

  • Anastasiya S. Sokolova Novosibirsk Institute of Organic Chemistry
  • Olga I. Yarovaya Novosibirsk State University
  • Anna A. Shtro Department of Chemotherapy, Research Institute of Influenza
  • Marina S. Borisova Novosibirsk Institute of Organic Chemistry
  • Ekaterina A. Morozova Novosibirsk Institute of Organic Chemistry
  • Tatyana G. Tolstikova Novosibirsk Institute of Organic Chemistry
  • Vladimir V. Zarubaev Department of Chemotherapy, Influenza Research Institute
  • Nariman F. Salakhutdinov Novosibirsk Institute of Organic Chemistry

DOI:

https://doi.org/10.1007/3651

Ключевые слова:

1H-benzimidazole-2-thiol, benzoxazole-2-thiol, benzthiazole-2-thiol, (–)-borneol, analgesic activity, antiulcer activity, antiviral activity

Аннотация

A series of novel heterocyclic derivatives of (–)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

 

Биографии авторов

Anastasiya S. Sokolova, Novosibirsk Institute of Organic Chemistry

Olga I. Yarovaya, Novosibirsk State University

Anna A. Shtro, Department of Chemotherapy, Research Institute of Influenza

Marina S. Borisova, Novosibirsk Institute of Organic Chemistry

Ekaterina A. Morozova, Novosibirsk Institute of Organic Chemistry

Tatyana G. Tolstikova, Novosibirsk Institute of Organic Chemistry

Vladimir V. Zarubaev, Department of Chemotherapy, Influenza Research Institute

Nariman F. Salakhutdinov, Novosibirsk Institute of Organic Chemistry

Загрузки

Опубликован

2017-04-07

Выпуск

Том 53 № 3 (2017): Предпочтительные гетероциклические структуры в химической биологии и разработке лекарств: синтез и биоактивность

Раздел

Оригинальные статьи