HETEROCYCLES AS CLASSICAL AND NONCLASSICAL RING B ISOSTERS IN COMBRETASTATIN A-4

Authors

  • Nikolay A. Zefirov Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991
  • Olga N. Zefirova Institute of Physiologically Active Compounds, Severny Proezd, 1, Chernogolovka, Moscow Region 142432

DOI:

https://doi.org/10.1007/3653

Keywords:

Combretastatin A-4, heterocycles, structure–activity relationship, isosteric replacement, cytotoxicity

Abstract

The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure–activity relationships are summarized.

Author Biographies

Nikolay A. Zefirov, Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991

Resercher

Olga N. Zefirova, Institute of Physiologically Active Compounds, Severny Proezd, 1, Chernogolovka, Moscow Region 142432

Professor of chemical department

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Published

2017-04-04

Issue

Vol. 53 No. 3 (2017): Privileged heterocyclic scaffolds in chemical biology and drug discovery: synthesis and bioactivity

Section

Review Articles