HETEROCYCLES AS CLASSICAL AND NONCLASSICAL RING B ISOSTERS IN COMBRETASTATIN A-4

Авторы

  • Nikolay A. Zefirov Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991
  • Olga N. Zefirova Institute of Physiologically Active Compounds, Severny Proezd, 1, Chernogolovka, Moscow Region 142432

DOI:

https://doi.org/10.1007/3653

Ключевые слова:

Combretastatin A-4, heterocycles, structure–activity relationship, isosteric replacement, cytotoxicity

Аннотация

The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure–activity relationships are summarized.

Биографии авторов

Nikolay A. Zefirov, Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow 119991

Resercher

Olga N. Zefirova, Institute of Physiologically Active Compounds, Severny Proezd, 1, Chernogolovka, Moscow Region 142432

Professor of chemical department

Загрузки

Опубликован

2017-04-04

Выпуск

Том 53 № 3 (2017): Предпочтительные гетероциклические структуры в химической биологии и разработке лекарств: синтез и биоактивность

Раздел

Обзорные статьи