REDUCTION OF 7-R DERIVATIVES OF 7<i>H</i>-TRIS[1,2,5]OXADIAZOLO[3,4-<i>b</i>:3′,4′-<i>d</i>:3″,4″-<i>f</i>]AZEPINE 1-OXIDE WITH FUROXAN RING OPENING. PREPARATION OF 4-R-4<i>H</i>-BIS[1,2,5]OXADIAZOLO[3,4-<i>b</i>:3′,4′-<i>f</i>]AZEPINE-8,9-DIAMINES

Abstract

It was shown that the reduction of derivatives of 7-R-7H-tris[1,2,5]oxadiazolo[3,4-b:3′,4′-d:3″,4″-f]azepine 1-oxide by hydrazine hydrate or hydrogen in the presence of palladium on carbon is accompanied by opening of the furoxan ring of the starting compound to the two amino groups and leads to the production of 4-R-4H-bis[1,2,5]oxadiazolo[3,4-b:3′,4′-f]azepine-8,9-diamines. Some chemical properties of the obtained diamino compounds are discussed.

Authors: A. I. Stepanov, D. V. Dashko, and A. A. Astrat'ev.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (7), pp 1068-1081

http://link.springer.com/article/10.1007/s10593-013-1345-7