ACTIVATION-FREE ONE-POT ALKYNYLATION–CYCLIZATION SYNTHESIS OF 2-SUBSTITUTED 4-AZAINDOLES AND INDOLES

Authors

  • Thomas J. J. Müller Heinrich Heine University Düsseldorf Institute of Organic Chemistry and Macromolecular Chemistry
  • Timo Lessing Institut für Organische Chemie und Makromolekulare Chemie, Lehrstuhl für Organische Chemie, Heinrich-Heine-Universität Düsseldorf

DOI:

https://doi.org/10.1007/4516

Keywords:

4-azaindoles, heterocycles, indoles, alkynylation, cyclization, one-pot reaction.

Abstract

2-Substituted 4-azaindoles and indoles are rapidly and efficiently prepared in an activation-free Pd-catalyzed alkynylation–cyclization sequence starting from 3-amino-2-bromopyridine or o-bromoaniline and terminal alkynes in a one-pot fashion.

Author Biography

Thomas J. J. Müller, Heinrich Heine University Düsseldorf Institute of Organic Chemistry and Macromolecular Chemistry

Institute of Organic Chemistry and Macromolecular Chemistry, chair of organic chemistry, director of institute

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Published

2018-05-15

Issue

Vol. 54 No. 3 (2018): Metal-catalyzed synthesis of heterocycles

Section

Original Papers