SYNTHESIS AND AMINOMETHYLATION OF REGIOISOMERIC 6-HYDROXY-4-METHYL- AND 4-HYDROXY-6-METHYLAURONES

Authors

  • Светлана П. Бондаренко Национальный университет пищевых технологий
  • Антонина В. Попова Институт биоорганической химии и нефтехимии НАН Украины
  • Михаил С. Фрасинюк Институт биоорганической химии и нефтехимии НАН Украины

DOI:

https://doi.org/10.1007/4710

Keywords:

benzofuran-3(2Н)-one, 4-hydroxy-6-methylaurone, 6-hydroxy-4-methylaurone, aminomethylation, Mannich bases.

Abstract

The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl- 6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The use of an excess of the aminals allows to obtain 5,7-bis(aminomethyl) derivatives of 6-hydroxy-4-methylaurones.

Published

2018-10-17

Issue

Section

Original Papers