STEREOSELECTIVE REDUCTION OF THE ACTIVE SUBSTANCE OF THE MEDICINAL PREPARATION DIMEBON TO THE CORRESPONDING <i>cis</i>- AND <i>trans</i>-1,2,3,4,4a,9b-HEXAHYDRO DERIVATIVES

Authors

  • Р. С. Алексеев Moscow M. V. Lomonosov State University, Moscow 199992
  • А. С. Иванов Moscow M. V. Lomonosov State University, Moscow 199992
  • А. В. Куркин Moscow M. V. Lomonosov State University, Moscow 199992
  • М. А. Юровская Moscow M. V. Lomonosov State University, Moscow 199992

DOI:

https://doi.org/10.1007/5252

Keywords:

Dimebon, 1, 2, 3, 4-tetrahydro-γ-carbolines, 4, 4a, 9b-hexahydro-γ-carbolines, stereoselective reduction

Abstract

Convenient preparative methods have been developed  for the reduction of the active substance of the medicinal preparation Dimebon (2,8-dimethyl-5-[2-(6-methylpyrid-3-yl)ethyl]-1,2,3,4-tetrahydro-γ-carboline) to the corresponding racemic cis-  and trans-1,2,3,4,4a,9b-hexahydro derivatives, distinguished by a high degree of stereoselectivity. The structures of the obtained diastereomeric hexahydro-γ-carbolines were confirmed by various physicochemical methods, including X-ray structural analysis.

How to Cite
Alekseyev, R. S.; Ivanov, A. S.; Kurkin, A. V.; Yurovskaya, M. A.  Chem. Heterocycl. Compd. 2010, 46, 1116. [Khim. Geterotsikl. Soedin. 2010, 1384.]

For this article in the English edition see DOI 10.1007/s10593-011-0658-7



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Published

2019-07-08

Issue

No. 10 (2010)

Section

Original Papers