SYNTHESIS OF NEW DERIVATIVES OF 3-ALKYL-5-ARYLAMINO-2,5-DIHYDROISOTHIAZOLE
Keywords:2-alkyl-5-arylimino-2, 5-dihydroisothiazoles, 2-substituted N-arylamides of 2-alkylaminobut-2 enethioic acid, enamine-imine tautomerism, oxidative cyclization
The cyclization of 2-substituted N-arylamides of 3-alkylaminobut-2-enethioic acid gave a series of new derivatives of 2-alkyl-5-arylimino-2,5-dihydroisothiazole containing a benzoyl or ester group at C-4. A study was carried out on the course of this reaction in the presence of various oxidizing agents, including halogens, N-bromosuccinimide, and hydrogen peroxide. Some of the isothiazoles obtained in this work demonstrated cytotoxic properties relative to both normal and cancer cell lines.
Authors: I. Skrastinya, A. Baran, and D. Muceniece
English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (4), pp 624-635