CYCLOCONDENSATION OF 2-IODOBENZALDEHYDE WITH BENZAMIDINES CATALYZED BY COPPER(I) IODIDE: A ROUTE TO 2-ARYLQUINAZOLINES

Authors

  • А. В. Выползов Санкт-Петербургский государственный университет, Санкт-Петербург 198504
  • Д. В. Дарьин Санкт-Петербургский государственный университет, Санкт-Петербург 198504
  • С. Г. Рязанов Санкт-Петербургский государственный университет, Санкт-Петербург 198504
  • П. С. Лобанов Санкт-Петербургский государственный университет, Санкт-Петербург 198504

DOI:

https://doi.org/10.1007/6205

Keywords:

benzamidine, 2-iodobenzaldehyde, quinazoline, catalysis by copper(I)

Abstract

The reaction of benzamidines with 2-bromo- and 2-iodobenzaldehydes catalyzed by the CuI/L-proline system has been studied. Reaction with 2-iodobenzaldehyde leads to the formation of quinazolines in good yield. 2-Bromobenzaldehyde forms 2-arylquinazolines in low yield due to the competing reaction involving two molecules of amidine leading to a dihydrotriazine.

How to Cite
Vypolzov, A. V.; Dar'in, D. V.; Ryazanov, S. G.; Lobanov, P. S.  Chem. Heterocycl. Compd. 2011, 46, 1481. [Khim. Geterotsikl. Soedin. 2010, 1833.]

For this article in the English edition see DOI 10.1007/s10593-011-0696-1

 

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Published

2021-03-22

Issue

No. 12 (2010)

Section

Original Papers