SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL PYRAZOLOPYRIDINE DERIVATIVES

Authors

  • N. Panda Department of Chemistry, National Institute of Technology, Rourkela-769008
  • S. Karmakar Department of Chemistry, National Institute of Technology, Rourkela-769008
  • A. K. Jena Department of Chemistry, National Institute of Technology, Rourkela-769008

DOI:

https://doi.org/10.1007/6208

Keywords:

heterocycles, pyrazolo[3, 4-b]pyridines, antimicrobial activity, disc diffusion method, Friedländer condensation

Abstract

Eight pyrazolo[3,4-b]pyridine derivatives have been synthesized by Friedländer condensation of 5-aminopyrazole-4-carbaldehyde with active methylene compounds in basic medium. These compounds have been screened for their antibacterial activity against two Gram-negative and two Gram-positive bacterium. Pyrazolopyridines having carboxamide group at 5-position showed moderate to good activity against P. aeruginosa, E. coli, S. pneumoniae, and B. cereus.

How to Cite

Panda, N.; Karmakar, S.; Jena, A. K. Chem. Heterocycl. Compd. 2011, 46, 1500. [Khim. Geterotsikl. Soedin. 2010, 1857.]

For this article in the English edition see DOI 10.1007/s10593-011-0699-y

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Published

2021-03-23

Issue

No. 12 (2010)

Section

Original Papers