SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NOVEL PYRAZOLOPYRIDINE DERIVATIVES

Авторы

  • N. Panda Department of Chemistry, National Institute of Technology, Rourkela-769008
  • S. Karmakar Department of Chemistry, National Institute of Technology, Rourkela-769008
  • A. K. Jena Department of Chemistry, National Institute of Technology, Rourkela-769008

DOI:

https://doi.org/10.1007/6208

Ключевые слова:

heterocycles, pyrazolo[3, 4-b]pyridines, antimicrobial activity, disc diffusion method, Friedländer condensation

Аннотация

Eight pyrazolo[3,4-b]pyridine derivatives have been synthesized by Friedländer condensation of 5-aminopyrazole-4-carbaldehyde with active methylene compounds in basic medium. These compounds have been screened for their antibacterial activity against two Gram-negative and two Gram-positive bacterium. Pyrazolopyridines having carboxamide group at 5-position showed moderate to good activity against P. aeruginosa, E. coli, S. pneumoniae, and B. cereus.

Загрузки

Опубликован

2021-03-23

Выпуск

№ 12 (2010)

Раздел

Оригинальные статьи