SYNTHESIS AND CYTOTOXICITY OF METHYL-SUBSTITUTED 8-QUINOLINESELENOLATES OF RUTHENIUM, RHODIUM, OSMIUM, AND IRIDIUM

Authors

  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006
  • Д. Зарума Inorganic Chemistry Institute of the Riga Technical University, Salaspils LV-2169
  • Я. Ашакс Inorganic Chemistry Institute of the Riga Technical University, Salaspils LV-2169
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • В. Бридане Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Ященко Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/6820

Keywords:

methyl-8-quinolineselenolates of iridium, osmium, rhodium, and ruthenium, synthesis, toxicity, cytotoxicity

Abstract

A series of 2-methyl, 4-methyl, and 2,4-dimethyl-8-quinolineselenolates of ruthenium, rhodium, osmium, and iridium has been synthesized and their cytotoxicity towards HT-1080 (human fibrosarcoma) and MG-22A (mouse hepatoma) tumor cells studied. It was found that all of the osmium complexes had a high cytotoxicity towards both cell lines. Their toxicity towards the normal mouse embryonic fibroblasts NIH-3T3 depends on the position and number of methyl groups in the quinoline ring and decreases in the order 2-Me > 4-Me > 2,4-Me2. The greatest selectivity in cytoxic activity is noted for iridium 4-methyl-8-quinolineselenolate and ruthenium 2-methyl-8-quinolineselenolate.

How to Cite
Lukevics. E.; Zaruma, D.; Ashaks, J.; Shestakova, I.; Domracheva, I.; Bridane, V.; Yashchenko, E.  Chem. Heterocycl. Compd. 2009, 45, 182. [Khim. Geterotsikl. Soedin. 2009, 230.]

For this article in the English edition see DOI 10.1007/s10593-009-0248-0


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Published

2022-05-23

Issue

No. 2 (2009)

Section

Original Papers