DIASTEREOSELECTIVE REDUCTIVE AMINATION OF PYRAZOLIDINYL ALKYL KETONES

Authors

  • Л. А. Свиридова Chemical Faculty, M. V. Lomonosov State Moscow University, Moscow 119899
  • Г. А. Голубева Chemical Faculty, M. V. Lomonosov State Moscow University, Moscow 119899
  • А. Н. Тавторкин A. N. Nesmeyanov Institute of Oganoelement Compounds, Russian Academy of Sciences, Moscow 119991
  • Ю. В. Нелюбина A. N. Nesmeyanov Institute of Oganoelement Compounds, Russian Academy of Sciences, Moscow 119991
  • К. А. Кочетков A. N. Nesmeyanov Institute of Oganoelement Compounds, Russian Academy of Sciences, Moscow 119991

DOI:

https://doi.org/10.1007/7053

Keywords:

primary and secondary amines, ketones, pyrazolidines, sodium triacetoxyborohydride, diastereoselective reductive amination

Abstract

Reductive amination of pyrazolidinyl alkyl ketones  with sodium triacetoxyborohydride or sodium tripivaloyloxyborohydride takes place diastereoselectively with the formation of aminoalkyl-pyrazolidines of trans structure.  The volume of the substituent in  the borohydrides does not affect the ratio of stereoisomers.

How to Cite
Sviridova, L. A.; Golubeva, G. A.; Tavtorkin, A. N.; Nelyubina, Yu. V.; Kochetkov, K. A.  Chem. Heterocycl. Compd. 2008, 44, 542. [Khim. Geterotsikl. Soedin. 2008, 691.]

For this article in the English edition see DOI 10.1007/s10593-008-0073-x


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Published

2022-09-15

Issue

No. 5 (2008)

Section

Original Papers