CONDENSED ISOQUINOLINES. 32. SYNTHESIS OF 4H-THIENO[3',2':5,6]- AND -[2',3':5,6]PYRIMIDO[1,2-<i>b</i>]ISOQUINOLINES AND 6,12-DIHYDRO-5H-ISOQUINO[2,3-<i>a</i>]QUINAZOLINE-5,12-DIONE DERIVATIVES

Authors

  • А. В. Задорожний Taras Shevchenko National University, Kiev 01033
  • В. А. Ковтуненко Taras Shevchenko National University, Kiev 01033
  • А. В. Туров Taras Shevchenko National University, Kiev 01033
  • Т. Т. Кучеренко Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/7121

Keywords:

isoquinoquinazoline-5, 12-dione, 4-oxopyrimidinones, thienopyrimidinones, thienopyrimidoisoquinoline-4, 11-diones, quinazolines

Abstract

Treatment of 2-(4-oxo-3,4-dihydrothieno[2,3-d]-  and -[3,2-d]pyrimidin-2-ylmethyl)benzoic acids and 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic acid with acetic anhydride gave thieno[3',2':5,6]- and -[2',3':5,6]pyrimido[1,2-b]isoquinoline-4,11-diones and isoquino[2,3-a]quinazoline-5,12-dione respectively. NMR spectroscopy showed that an intramolecular acylation of the above acids occurs at the atom N-1 of the pyrimidinone part of the bicycle.

How to Cite
Zadorozhny, A. V.; Kovtunenko, V. A.; Turov, A. V.; Kucherenko, T. T.  Chem. Heterocycl. Compd. 2008, 44, 845. [Khim. Geterotsikl. Soedin. 2008, 1053.]

For this article in the English edition see DOI 10.1007/s10593-008-0119-0


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Published

2022-10-07

Issue

No. 7 (2008)

Section

Original Papers