4-HYDROXY-2-QUINOLONES. 114. SYNTHESIS AND STRUCTURE OF 6-R-5-HYDROXY-2,4-DIOXO-2,3,4,6-TETRAHYDROBENZO[<i>c</i>][2,7]NAPHTHYRIDINE-1-CARBONITRILES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • Н. Л. Березнякова National University of Pharmacy, Kharkiv 61002
  • В. А. Паршиков National University of Pharmacy, Kharkiv 61002
  • С. В. Шишкина Institute of Scintillation Materials, National Academy of Sciences of Ukraine, Kharkiv 61001

DOI:

https://doi.org/10.1007/7526

Keywords:

benzonaphthyridine, 4-chloro-3-ethoxycarbonyl-2-quinolinone, malononitrile, cyanoacetamide, hydrolysis, X-ray analysis

Abstract

Hydration of ethyl 1-R-4-dicyanomethyl-2-oxo-1,2-dihydroquinoline-3-carboxylate gives the corresponding substituted cyanoacetamides which are  readily and quantitatively cyclized to 6-R-5-hydroxy-2,4-dioxo-2,3,4,6-tetrahydrobenzo[c][2,7]naphthyridine-1-carbonitriles in the presence of aqueous base.

How to Cite
Ukrainets, I. V.; Bereznyakova, N. L.; Parshikov, V. A.; Shishkina, S. V.  Chem. Heterocycl. Compd. 2007, 43, 608. [Khim. Geterotsikl. Soedin. 2007, 726.]

For this article in the English edition see DOI 10.1007/s10593-007-0095-9

 

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Published

2023-03-21

Issue

No. 5 (2007)

Section

Original Papers