4-HYDROXY-2-QUINOLONES. 112. REACTION OF 2-ETHOXYCARBONYLMETHYL-4H-3,1-BENZOXAZIN-4-ONE WITH ACTIVE METHYLENE COMPOUNDS

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkiv 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv 61002
  • С. В. Слободзян Ohio Northern University, Ada, Ohio 45810

DOI:

https://doi.org/10.1007/7702

Keywords:

4H-3, 1-benzoxazin-4-one, 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxamides, active methylene compounds

Abstract

The reaction of 2-ethoxycarbonylmethyl-4H-3,1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3,6-dioxo-4,6-dihydro-3H-pyrimido[1,2-a]quinoline-5-carbonitrile. Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid while diethyl malonate gives N,N' -di-2-carboxyanilides of malonic acid.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Slobodzyan, S. V.  Chem. Heterocycl. Compd. 2007, 43, 63. [Khim. Geterotsikl. Soedin. 2007, 75.]

For this article in the English edition see DOI 10.1007/s10593-007-0009-x

 

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Published

2023-04-06

Issue

No. 1 (2007)

Section

Original Papers