THE REACTION OF 2-HETARYLACETONITRILES WITH HETEROCYCLIC HALOALDEHYDES

Authors

  • О. В. Хиля Taras Shevchenko Kiev National University, Kiev 01033
  • Т. А. Воловненко Taras Shevchenko Kiev National University, Kiev 01033
  • Ю. М. Воловенко Taras Shevchenko Kiev National University, Kiev 01033

DOI:

https://doi.org/10.1007/7781

Keywords:

1-aryl-3-methyl-1H-benzo[4, 5]imidazo[1, 2-a]pyrazolo[4, 3-e]pyridine-5-carbonitrile, 1-aryl-3-methyl-11-oxo-1, 11-dihydropyrazolo[4', 3', 5, 6]pyrido[2, 1-b]quinazoline-5-carbonitrile, 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde, 3-(1-aryl-5-chloro-3-methyl-1H-4-pyrazolyl)-2-benzimidazolyl-2-propenenitrile, benzimidazolylacetonitrile, 15-oxo-15H-benzo[6, 7][1, 8]naphthyridino[2, 1-b]-quinazoline-6-carbonitrile, 4-oxo-3, 4-dihydroquinazolylacetonitrile, 3-(1-aryl-5-chloro-3-methyl-1H-4-pyrazolyl)-2

Abstract

The reaction of 4-oxo-3,4-dihydroquinazolyl- and benzimidazolylacetonitriles with 2-chloro-2-quinolinecarbaldehydes and 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehydes gave the corresponding 3-(2-chloro-3-quinolyl)-2-(4-oxo-3,4-dihydro-2-quinazolyl)-2-propenenitriles and 3-(1-aryl-5-chloro-3-methyl-1H-4-pyrazolyl)-2-hetaryl-2-propenenitriles. Intramolecular cyclization of these compounds gives 15-oxo-15H-benzo[6,7][1,8]naphthyridino[2,1-b]quinazoline-6-carbonitriles, 1-aryl-3-methyl-11-oxo-1,11-dihydropyrazolo[4',3':5,6]pyrido[2,1-b]quinazoline-5-carbonitriles, and 1-aryl-3-methyl-1H-benzo[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyridine-5-carbonitriles.

How to Cite
Khilya, O. V.; Volovnenko, T. A.; Volovenko, Yu. M.  Chem. Heterocycl. Compd. 2006, 42, 1311. [Khim. Geterotsikl. Soedin. 2006, 1520.]

For this article in the English edition see DOI 10.1007/s10593-006-0241-9


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Published

2023-05-12

Issue

No. 10 (2006)

Section

Original Papers