POLYFUNCTIONAL PYRAZOLES. 4. SYNTHESIS OF 3-[3-ARYL-1-(2-ETHOXYCARBONYL)-4-PYRAZOLYL]ACRYLIC AND -PROPIONIC ACIDS

Authors

  • М. К. Братенко Bukovinian State Medical Academy, Chernovtsy 58000
  • В. А. Чорноус Bukovinian State Medical Academy, Chernovtsy 58000
  • М. В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094

DOI:

https://doi.org/10.1007/7972

Keywords:

3-(4-formyl-1-pyrazolyl)propionic acids, 3-(4-pyrazolyl)acrylic acids, 3-(4-pyrazolyl)propionic acids, microwave activation, reduction

Abstract

3-(3-Aryl-4-formyl-1-pyrazolyl)propionic acids  are converted by Knoevenagel condensation under conditions of microwave activation into 3-[3-aryl-1-(2-ethoxycarbonyl)-4-pyrazolyl]acrylic acids. Reduction of the latter with hydrazine hydrate in the presence of Raney nickel gives 3-[3-aryl-1-(2-ethoxycarbonyl)-4-pyrazolyl]propionic acids.

How to Cite
Bratenko, M. K.; Chornous, V. A.; Vovk, M. V.  Chem. Heterocycl. Compd. 2006, 42, 600. [Khim. Geterotsikl. Soedin. 2006, 686.]

For this article in the English edition, see DOI 10.1007/s10593-006-0133-z


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Published

2023-08-17

Issue

No. 5 (2006)

Section

Original Papers