REGIOSELECTIVE SYNTHESIS AND PROPERTIES OF 6-AMINO-3-CARBAMOYL-5-CYANO-3,4-DIHYDROSPIROCYCLOHEXANE-4-PYRIDINE-2-THIOL AND 5-CYANO-3-THIOCARBAMOYL-4-SPIROCYCLOHEXANEPIPERIDINE-2,6-DIONE

Authors

  • A. D. Dyachenko Taras Shevchenko National Pedagogical University, Lugansk 91011
  • S. M. Desenko V. N. Karazin National University, Kharkov 61070
  • V. D. Dyachenko Taras Shevchenko National Pedagogical University, Lugansk 91011

Keywords:

3,4-dihydrospirocyclohexane-4-pyridine-2-thiol, monothiomalonodiamide, spirocyclohexane-4-piperidine-2,6-dione, cyclohexylidenemalononitrile, cyclohexylidenecyanoacetic ester, alkylation, hydrolysis, Michael reaction, regioselective synthesis, cyclization, cyclocondensation

Abstract

Treatment of monothiomalonodiamide with cyclohexylidenemalononitrile or cyclohexylidenecyanoacetic ester in the presence of sodium ethylate gave 6-amino-3-carbamoyl-5-cyano-3,4-dihydrospirocyclohexane-4-pyridine-2-thiol and 5-cyano-3-thiocarbamoyl-4-spirocyclohexane-piperidine-2,6-dione. Their alkylation and hydrolysis have been studied.

How to Cite
Dyachenko, A. D.; Desenko, S. M.; Dyachenko, V. D. Chem. Heterocycl. Compd. 2004, 40, 1017. [Khim. Geterotsikl. Soedin. 2004, 1179.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000046691.85029.7a

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Published

2004-08-25

Issue

No. 8 (2004)

Section

Original Papers