PURINE NUCLEOSIDE ANALOGS. 12. SYNTHESIS OF NOVEL 8,9-DISUBSTITUTED GUANINE DERIVATIVES BY S-ALKYLATION OF 2-ACETAMIDO-9-(2-ACETOXYETHOXYMETHYL)-6-OXO-8-THIOXOPURINE

Abstract

S-Alkylation of 2-acetamido-9-(2-acetoxyethoxymethyl)-6-oxo-8-thioxopurine was used to synthesize its novel S- and N₍₇₎-substituted derivatives. We have established the effect of the structure of the alkylating agent on the reaction conditions and its regioselectivity. We have shown that the synthesized guanine derivatives can be modified further.

How to Cite
Ikaunieks, M.; Madre, M. Chem. Heterocycl. Compd. 2003, 39, 244. [Khim. Geterotsikl. Soedin. 2003, 274.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1023732827820