SELECTIVE REDUCTION OF 5,7-DINITRO-8-HYDROXYQUINOLINE AND SYNTHESIS OF 2-SUBSTITUTED 5-NITROOXAZOLO[4,5-<i>h</i>]QUINOLINES

Authors

  • Il'ya I. Ustinov Tula State Lev Tolstoy Pedagogical University, 125 Lenina Ave., Tula 300026
  • Nikolai V. Hlytin Tula Pharmaceutical Factory, 10 Torkhovsky Proyezd, Tula 300004

Keywords:

nitroquinolines, 5,7-dinitro-8-oxyquinoline, 7-amino-5-nitroquinolin-8-ol, 5-nitrooxazolo[4,5-h]quinolines, Zinin reaction, chemical reduction, catalytic hydrogenation, cyclocondensation

Abstract

Chemoselective reduction of the ortho-nitro group in 5,7-dinitro-8-oxyquinoline was carried out by the action of Na2S in H2O and DMSO as well as by hydrogenation on 0.8% Pd/C. A number of new 2-substituted 5-nitrooxazolo[4,5-h]quinolines were obtained starting from the synthesized 7-amino-5-nitroquinolin-8-ol.

Author Biography

Il'ya I. Ustinov, Tula State Lev Tolstoy Pedagogical University, 125 Lenina Ave., Tula 300026

научный сотрудник кафедры химии

интересы - гетероциклические нитросоединения

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Published

2024-12-13

Issue

Vol. 60 No. 9/10 (2024)

Section

Original Papers